Novartis statement on reported case of PML

Novartis statement on reported case of PML

INforMS, Partners

Novartis Statement on Reported Case of PML

Novartis has been informed of a patient with progressive multifocal leukoencephalopathy (PML). The patient had been diagnosed with ulcerative colitis (an autoimmune bowel disease) in 2011 and had been treated with oral mesalazine since February 2011. At the end of 2012, the patient started treatment with Gilenya® (fingolimod) for the management of relapsing MS (RMS). This is the second case of PML in an MS patient being treated with Gilenya who did not haveprevious use of Tysabri® (natalizumab).

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The industry news information and articles are for informational purposes only, and are not intended to represent any trends, partnerships, commitments, or research of the Consortium of MS Centers or any of it's members in any way whatsoever, nor should any party be libel in any way to the reader or to any other person, firm or corporation reading this industry news section. Although the CMSC site includes links providing direct access to other Internet sites, CMSC takes no responsibility for the content or information contained on those other sites, and does not exert any editorial or other control over those other sites. CMSC is providing information and services on the Internet as a benefit and service in furtherance of CMSC's nonprofit and tax-exempt status. CMSC makes no representations about the suitability of this information and these services for any purpose.

Elizabeth Porco

The Siegel Rare Neuroimmune Association Marks 30 Years of Improving Quality of Life for People With Rare Neuroimmune Disorders

The Language of MS: How Much Does It Matter?

Genentech’s Ocrevus Twice-Yearly, 10-Minute Subcutaneous Injection Was Non-Inferior to Intravenous Infusion and Provided Near-Complete Suppression of Brain Lesions

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Is it MS or Something Else? updated guide is published to expedite and uncover the answer

Positive Phase III results for Genentech’s Ocrevus (ocrelizumab)

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NeurologyLive® and CMSC announce Giants of Multiple Sclerosis® 2023 class of inductees

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Multiple sclerosis discovery could end disease’s chronic inflammation

Congratulations to Dr. Carrie Hersh for her recent publication on DMTs

The launch of the ROADMAP tool on Rare Disease Day 2023

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Meghan Beier recently joined the Rowan Center for Behavioral Health

Helius launches UpScript telehealth e-commerce site

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A new patient assistance offering from Janssen

Cycle Pharmaceuticals to launch TASCENSO ODT® (fingolimod) in US in Q1 2023

Genentech to present new Ocrevus (ocrelizumab) data in multiple sclerosis & NMOSD research at ECTRIMS

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US FDA – Ocrevus prescribing information to include warnings for Colitis and PML

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Janssen Pharmaceuticals U.S. transparency report

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Genentech premiers #MSVisibility 2022

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Sanofi’s 2022 annual pricing principles report

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New preclinical tolebrutinib data demonstrated superior brain penetration and potency

MR epectroscopic imaging may help better diagnose, treat multiple sclerosis

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NeurologyLive® announces the inaugural Giants of Multiple Sclerosis™ Program

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The Brain Under Siege by Dr. Howard Weiner

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Introducing Atara Biotherapeutics: the role of EBV in multiple sclerosis and the Phase II EMBOLD study

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MRI in Multiple Sclerosis Guidelines Update: North America, Europe align on new recommendations

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Study on cognitive processing speed changes in RMS subjects treated with Ozanimod

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#MSVisibility virtual concert: recording now available

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Phase 1/2 study to evaluate the safety and efficacy of ATA188 in progressive multiple sclerosis

New data for Ocrevus disease progression (ocrelizumab) reinforce significant slowing

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New Genentech data at 2021 AAN highlight impact & breadth of neuroscience portfolio

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FDA approval of intramuscular Plegridy (Peginterferon beta-1a)

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Genentech’s enspryng for Neuromyelitis Optica Spectrum Disorder

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Mylan brings critical access to the multiple sclerosis community

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WHO and AMA statement

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A letter from Lemtrada regarding its home phlebotomy partner, EMSI

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Inebilizumab approved for treatment of Neuromyelitis Optica Spectrum Disorder

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Multiple sclerosis and COVID-19 registry

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Robotic ‘trousers’ could help thousands of multiple sclerosis sufferers stand and walk again

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Use of DMTs changing ‘natural history’ of relapsing multiple sclerosis, study says

FDA approves first generics for common multiple sclerosis drug

Results for Genentech’s Satralizumab in Neuromyelitis Optica Spectrum

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NeurologyLive™ adds CMSC to its Strategic Alliance Partnership program

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Kessler scientists receive grant to study exercise benefits in multiple sclerosis

EMD Serono initiates pivotal Phase III program for investigational Evobrutinib in RMS

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Genentech presents new six-year Ocrevus (Ocrelizumab) data

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Genentech’s Satralizumab significantly reduced relapse risk

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Genentech presents new Ocrevus (Ocrelizumab) biomarker data

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Dr. Daniel Kantor highlights multiple sclerosis treatments and what is in the pipeline

Multiple sclerosis relationships improved by togetherness and communication, study suggests

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Press release – Genentech to present piviotal data at ECTRIMS

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Social cognition, mood and fatigue in multiple sclerosis

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Rutgers Health leading program to support multiple sclerosis children

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Dr. Anne Cross discusses strides In multiple sclerosis research, recent award

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EMD Serono’s embracing carers launches ‘Time Counts’ to raise 1M minutes of support

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CMSC opens weeklong mental health program to help mentor and train multiple sclerosis specialists

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Alexion’s Soliris gets new, and lucrative, rare disease indication

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Kessler researchers explore social cognitive deficits in progressive multiple sclerosis

CMSC, multiple sclerosis non-profits and Polar Products recognizes over twenty years of progress

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Billings Clinic hosts its first multiple sclerosis health and well-being symposium

Lenox Hill Hospital multiple sclerosis support group

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UCLA researchers work to advance treatment targeting source of multiple sclerosis

Genentech presenting new Ocrevus (Ocrelizumab) data at AAN Meeting

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MSAA recognizes ten years of artwork from individuals with multiple sclerosis

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FDA approves MAVENCLAD® (Cladribine) tablets

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Anne Cross, neurologist with pioneering work into B-cells/multiple sclerosis, awarded John Dystel Prize

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Novartis gets FDA approval for Mayzent (Siponimod), the first oral drug to treat SPMS

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Novartis receives FDA approval for MAYZENT (Siponimod)

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Dose-finding study for SAR442168 in relapsing multiple sclerosis

BrainStorm announces first patient in phase 2 clinical trial progressive multiple sclerosis

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FDA accepts BrainStorm’s NurOwn® IND application for progressive multiple sclerosis

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Novartis announces PARADIGMS study demonstrating benefit of Gilenya®

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AAN publishes guideline on disease-modifying therapies for multiple sclerosis

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New Ocrevus (Ocrelizumab) data demonstrate reductions In activity & progression In RMS

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Imagerywork

Phase III data in the lancet show Novartis outcomes in secondary progressive multiple sclerosis

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Abbvie and Biogen pull multiple sclerosis drug Zinbryta following urgent EMA safety review

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CVS/Aetna combo a formidable pharma rival when it comes to access

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Fruits and vegetables may help reduce symptoms of multiple sclerosis: study

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Increased epilepsy risk identified in multiple sclerosis

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National Multiple Sclerosis Society endorses multiple sclerosis “NARCRMS” data registry

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Mayo Clinic develops test to distinguish other demyelinating diseases from multiple sclerosis

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Cognitive impairment worse among PPMS than RMS patients, German study fnds

International Journal of Multiple Sclerosis Care wins 2017 APEX Award

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OMRF multiple sclerosis center wins top multiple sclerosis research award

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Research sheds light on who’s multiple sclerosis could worsen

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Sodium intake and its association with multiple sclerosis progression

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New multiple sclerosis drug, backed by 40 years of research, could halt disease

‘MS From the Inside Out’ uses virtual reality to share what life for patients is like

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Bayer receives FDA approval of myBETAapp™ and BETACONNECT Navigator™

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CMSC 2017 Annual Meeting – Celgene’s investigational therapy Ozanimod safe, effective in treating RMS

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CMSC 2017 Annual Meeting – Rituxan-treated multiple sclerosis patients three times more likely to have improved brain scans

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CMSC 2017 Annual Meeting – review suggests certain multiple sclerosis patient groups may discontinue DMTs

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CMSC 2017 Annual Meeting – Tysabri improves mental outlook for patients with secondary progressive MS

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CMSC 2017 Annual Meeting – multiple sclerosis patients should contribute to outcome measure development, study argues

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CMSC 2017 Annual Meeting – single session of ball-throwing exercise improves balance control in multiple sclerosis

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CMSC 2017 Annual Meeting – Genentech starts site to connect multiple sclerosis patients and caregivers with resources

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David Sackett trial of the year awarded to the Oratorio Study

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CMSC 2017 Annual Meeting – experts to focus on multiple sclerosis patient care at CMSC Annual Meeting in New Orleans

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Biogen Idec to present new two-year data from the PLEGRIDY phase 3 advance study

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New survey finds multiple sclerosis patients struggle with misdiagnosis and invisible symptoms

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Glove with sensors measures spasticity more accurately than physicians

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Researchers analyze multiple sclerosis life expectancy, survival and mortality in 60-year study

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Here’s How You Can Prevent, Manage Multiple Sclerosis

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Horseback Riding Helps People with Movement Disabilities, Review of 16 Studies Concludes

People with MS are Three-six Times More Prone to Seizures than Others, Study Reports

Multiple Sclerosis – New Technology Improves Cognition

11 Subtle Early Signs of Multiple Sclerosis – The Sooner You Catch it the Better

HackensackUMC Opens Multiple Sclerosis Center

First Blood Biomarker for Multiple Sclerosis Discovered

MS – New Blood Test Can Identify Types of MS and if Treatments are Working

Generic Form of Copaxone, GTR, Safe and Effective, Study Confirms

Researchers fFnd Clues to Multiple Sclerosis in Blood

Sense of Smell is Impaired in Half of Multiple Sclerosis Patients in Study

Epileptic Seizures in Multiple Sclerosis May Suggest Shared Pathology

Grief, Self-Preservation and Multiple Sclerosis

Template Improves Quality of Report on MRI for Multiple Sclerosis

Ocrelizumab Shown Effective Against Relapsing, Progressive Forms of Multiple Sclerosis

21st Century Cures Act Expected to Bring Real Change to MS patients’ Lives

Ari Waisman receives most prestigious European prize for multiple sclerosis research

Multiple Sclerosis – Better Ways to Test Diet Changes

Imbalances in Brain Microbiota May be Behind Demyelination in MS, Study Says

Low Vitamin D Levels at Birth May Influence MS Risk in Adults, Study Suggests

ICER Releases Draft Report on Disease-Modifying Therapies for MS, Welcomes Comment

UV Light May Lead Way to New Treatment for MS and Inflammation

Acorda to Discontinue Dalfampridine for Treatment of Post-Stroke Walking Difficulties

Genentech Results from Survey that Shows Everyday Impact of Unpredictable MS Symptoms

Men & Women Seem to Differ in Genetic Susceptibility to MS & its Progression in Study

Immune System May Harbor Natural Way of Fighting MS, Other Autoimmune Diseases

Posture Difficulties in MS Linked to Areas of Nervous System Most Damaged by Disease

‘Rare’ Molecule in Immune System is Common and May be Part of What Goes Wrong in MS

Selective Manipulation of Specific Receptors May Pave Way for New MS Therapies

Multiple Sclerosis Drug Could Reverse Physical Symptoms

Multiple Sclerosis Research Finds Running ‘Could Help Prevent’ Notorious Disease

United Spinal Association offering range of materials at exhibit booth at CMSC 2016 Annual Meeting

CMSC PR, Partners

Daclizumab Approved (zinbryta tm) for Relapsing Forms of Multiple Sclerosis

Scientists Develop System for Early Diagnosis of Parkinson’s, MS, and Alzheimer’s

Tysabri May be More Effective than Gilenya at Reducing Disease Activity in MS Patients

Lifelong Exercise Doesn’t Lower the Risk of MS, Large Study in Women Reports

Satisfaction with MS Therapy Influenced by Doctor-Patient Communication, Study Finds

MS More Frequent Among Females Exposed to High Levels of Copper, Study Shows

How Tecfidera Works to Reduce MS Relapses Discovered, May Lead to Better Treatments

Protein Biomarker Identified for MS May Predict Disease Severity, Treatment Response

Experimental Drug May Prevent Development of Multiple Sclerosis in Mice

8 less common symptoms of multiple sclerosis

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Can multiple sclerosis be detected by biomarkers in the blood? yes, study says

Multiple sclerosis diagnosis and treatment: scientist challenge study linking gene to the condition

Multiple sclerosis treatments may lower levels of immune white blood cells

Blood test seen to distinguish multiple sclerosis from other neurological conditions

Specific definition of fatigue in multiple sclerosis proposed as way to advance research into symptom

Researchers develop technology for treating multiple sclerosis with gaming cameras

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Alleviating multiple sclerosis symptoms possible with yoga and aquatic exercises

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Early treatment of multiple sclerosis (MS) symptoms extends diagnosis time

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Multiple sclerosis rehabilitation specialist, Susan Bennett, receives CMSC Lifetime Achievement Award

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Multiple sclerosis risk higher in children and adolescents with type 1 diabetes: study

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Scientists believe to discover ‘breakthrough’ cure for multiple sclerosis/type 1 diabetes

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9 approved multiple sclerosis therapies you should know about

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Multiple sclerosis patients’ personal circumstances largely shape their views on therapy preferences

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Clean scans sustained with Siponimod in multiple scleorsis

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Microbiome study reveals inflammatory pathways linked to multiple sclerosis

High blood pressure in multiple sclerosis seen to increase risk of disability progression

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Elevated BMI: a modifiable risk factor for multiple sclerosis?

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Scientists develop a drug for the treatment of multiple sclerosis

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Micro-RNA levels may be diagnostic marker, distinguishing multiple sclerosis from other diseases

Multiple sclerosis-related optic neuropathy can be reversed with allergy drug (antihistamine): study

Multiple sclerosis development: what is clinically isolated syndrome (CIS)?

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Four new risk genes associated with multiple sclerosis discovered

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Clinical pilates seen to improve both cognition and muscle strength in multiple sclerosis patients

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CMSC 2016 Annual Meeting – Clay Walker’s concert at the CMSC 30th anniversary celebration

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Sleep impacts cognitive function in multiple sclerosis patients

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Gray matter atrophy tied to specific disabilities in multiple sclerosis

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Processed foods and additives may lead to multiple sclerosis, autoimmune diseases

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CMSC 2016 Annual Meeting – Multiple Sclerosis News Today’s exclusive interview with Summer Kernan

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Multiple sclerosis therapy can ‘reverse disease’

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CMSC 2016 Annual Meeting – Fingolimod (Gilenya) offers consistent health benefits in RRMS patients

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‘Multiple sclerosis does not remit’ – call to change RRMS name to relapsing multiple sclerosis

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CMSC 2016 Annual Meeting – multiple sclerosis patients, physical therapists have distinct decision-making processes

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CMSC 2016 Annual Meeting – multiple sclerosis duration and disability level variously impacts arm function

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CMSC 2016 Annual Meeting – multiple sclerosis and yoga: author and instructor says ancient discipline can help patients

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CMSC 2016 Annual Meeting – Ocrevus (Ocrelizumab) in PPMS prevented disability progression

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Sluggish bowels may increase fatigue in multiple sclerosis

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Mitoxantrone may boost colon cancer risk in multiple sclerosis

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Today is World Multiple Sclerosis Day

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Multiple sclerosis and young adult-onset hodgkin lymphoma may share underlying causes, study says

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Study of viral infection revives possibility of link between multiple sclerosis and viruses

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At-home ‘brain training’ program for multiple sclerosis patients to improve cognitive skills by 29%

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Multiple sclerosis risk may increase with obesity in children and teens

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Study associates obesity in youth, low Vitamin D levels with multiple sclerosis onset and progression

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Multiple sclerosis treatment, faster MRI diagnosis method helps reduce brain inflammation

Young multiple sclerosis patients in United States more likely overweight & suffer relapses than peers – study

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Alemtuzumab (Lemtrada) seen to slow disease progression by targeting key brain systems

Plant peptide could prevent onset of multiple sclerosis

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New role of environment in multiple sclerosis revealed

Brain training video games ‘can soothe symptoms of multiple sclerosis’

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Can drinking lots of coffee lower risk for multiple scleorsis?

Ocrelizumab benefit in PPMS consistent in subgroups

Wearable robotic exoskeleton may enable multiple sclerosis patients to walk more efficiently

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FDA grants breakthrough therapy for Ocrelizumab for PPMS

Multiple sclerosis patients may lose ability to taste

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Multiple sclerosis study finds lipid antibodies reflect changes in brainvolume and lesions

Multiple sclerosis patients seen to safely switch to oral drugs from injectable oral therapies

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Adaptive yoga for multiple sclerosis

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New MRI technique offers faster diagnosis of multiple sclerosis

Beyond first-line: Natalizumab vs Fingolimod for RRMS

Study details source of mental problems associated with multiple sclerosis

No early risk when stable multiple sclerosis patients switch to oral drugs

Epilepsy drug ‘could help multiple sclerosis patients’

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Multiple sclerosis (MS) patients showing progress with cancer treatment

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Obstructive sleep apnea, sleep disorders may contribute to multiple sclerosis fatigue

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Multiple sclerosis bladder control problems include incontinence and nocturia

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Multiple sclerosis eye problems: optic neuritis, nystagmus and diplopia

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Francois Bethoux, MD, named medical director of the Arts & Medicine Institute

Multiple sclerosis clinical trials more successful than other diseases

High dose vitamin D could treat multiple sclerosis, scientists find

National Multiple Sclerosis Society honors physician

Can we vaccinate against PML in multiple sclerosis?

MedDay misses endpoint in phase III multiple sclerosis vision loss trial

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Brain cell death may cause multiple sclerosis

New drug is first to treat Progressive Multiple Sclerosis

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Poor visual symptoms in multiple sclerosis patients

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Multiple sclerosis and the prevalence of sleep disorders, epileptic seizures

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Multiple sclerosis causes psychiatric symptoms

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Cellular target opens new pathway for multiple sclerosis therapy

How multiple sclerosis can be triggered by brain cell death

Pregnancy hormone could keep multiple sclerosis at bay

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Trigeminal neuralgia, type of nerve pain, is an early multiple sclerosis symptom

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Exploring new paths for the treatment of multiple sclerosis

Biogen reports top-line results from phase 3 study evaluating Natalizumab in SPMS

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EMD Serono announces publication of PRISMS-15 year follow-up study using Rebif in RRMS

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Treatment effects maintained over 5 years in patients with RRMS who received Lemtrada

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Genentech’s Ocrelizumab show positive pivotal study results in both RRMS and PPMS

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EMD Serono announces recipients of the third annual €1 million grant for multiple sclerosis innovation

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Results from ZINBRYTA phase 3 DECIDE study presented at ECTRIMS

New analysis suggests Aubagio slows brain atrophy in people with Relapsing MS

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Data show effects of TECFIDERA in newly-diagnosed and early disease course multiple sclerosis patients

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Opexa announces granting of new t-cell patents covering tcelna

Genzyme introduces “vs.MS”, a global initiative

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Genentech’s Ocrelizumab to show efficacy in people with PPMS in large phase III study

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Bayer receives FDA approval for BETACONNECT

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Novartis acquires all remaining rights to GSK Ofatumumab to develop treatments for multiple sclerosis

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EMD Serono and Opexa amend agreement to support ongoing development of Tcelna for multiple sclerosis

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Pfizer & Synthon enter Into U.S. commercialization agreement for treatment of multiple sclerosis

FDA: Gadolinium-based MRI contrast agents pose possible brain risk

Multiple Sclerosis Coalition applauds passage of 21st Century Cures Act

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Genentech’s Ocrelizumab reduced both relapses and disability progression versus Rebif

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Multiple Sclerosis Coalition announces new board President

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Sandoz announces US launch of Glatopa, the first generic competitor to Copaxone 20mg

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FDA accepts biologics license application for ZINBRYTA for treatment of multiple sclerosis

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Mallinckrodt research fellowship award program announcement

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FDA accepts filing of BETACONNECT for RRMS patients taking BETASERON

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International survey identifies opportunities for improving multiple sclerosis treatment satisfaction

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PLEGRIDY three-year data support long-term safety and efficacy in multiple sclerosis patients

TECFIDERA Data Reinforce Strong, Sustained Efficacy for Newly-Diagnosed MS Patients

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The FDA approves a generic form of Copaxone

People with multiple sclerosis may have trouble recognizing emotions

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EMA validates marketing authorization application for ZINBRYTA for treatment of multiple sclerosis

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Teva Neuroscience & Access Health team up for special multiple sclerosis awareness show: thursday, 3/5

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Multiple sclerosis paroxysmal symptoms confused with seizures due to sudden onset

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How Vitamin D repairs myelin in multiple sclerosis

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Acorda announces data from first clinical trial of remyelinating antibody in multiple sclerosis

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First multiple sclerosis patients in the U.S. receive Genzyme’s Lemtrada following FDA approval

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Genzyme’s Lemtrada approved by the FDA

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Genzyme announces enrollment of first patient in phase II Vatelizumab trial in RRMS

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Study on abnormal MRIs and the risk of developing multiple sclerosis featured in the IJMSC

Optimizing multiple sclerosis management – new CME/CE courses for healthcare professionals

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Results from two phase III studies added to U.S. label of Genzyme’s Aubagio

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Employment in Multiple Sclerosis (MS) study

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Novartis teams up with multiple sclerosis advocate David Osmond to launch Our Voice in Song

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At four years, treatment effect maintained in patients who received Lemtrada in studies

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New international survey finds multiple sclerosis patients and neurologists view communication positively

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IJMSC features article on the Multiple Sclerosis Self-Management Scale

AIMS presents the latest on multiple sclerosis treatments

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Biogen Idec’s PLEGRIDY approved in the US for the treatment of multiple sclerosis

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PLEGRIDY (Peginterferon beta-1a) approved in the EU for the treatment of multiple sclerosis

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Teva files citizen petition with the US FDA regarding the complexity of COPAXONE

INforMS, Partners

Genzyme’s Lemtrada approved in Argentina for treatment of multiple sclerosis

INforMS, Partners

Biogen Idec and AbbVie Announce Results from Phase 3 Study Investigating Daclizumab

INforMS, Partners

Genzyme’s Lemtrada resubmission accepted for review by FDA

INforMS, Partners

Data from Biogen Idec’s portfolio of multiple sclerosis therapies and pipeline featured at congresses

INforMS, Partners

Biogen Idec announces official partnership with Sailing Sclerosis’ “Oceans of Hope”

INforMS, Partners

EMD Serono data at CMSC & ACTRIMS Annual Meeting reinforces proven efficacy of rebif

CMSC PR, Partners

Acorda Therapeutics to showcase online multiple sclerosis resources at 2014 CMSC/ACTRIMS meeting

CMSC PR, Partners

Genzyme recognizes sixth annual World MS Day

INforMS, MS Community, Partners

CHMP adopts positive opinion for PLEGRIDY as a treatment for multiple sclerosis in the EU

INforMS, Partners

Opexa reaches enrollment target in phase IIb trial of personalizedimmunotherapy for SPMS

Teva announces COPAXONE recognized as “Brand of the Year” by Pharm Exec Magazine

INforMS, Partners

New TYSABRI analysis shows improved walking speed in significant number of multiple sclerosis patients

INforMS, Partners

New data reinforce efficacy of TECFIDERA in multiple sclerosis patients with high disease activity

INforMS, Partners

A farewell tribute to Mike Robinson – President, National Multiple Sclerosis Society of Zimbabwe

Slowing of brain atrophy sustained at three years in patients treated with Lemtrada

INforMS, Partners

Genzyme announces multi-year multiple sclerosis research collaboration with academic medical center

INforMS, Partners

Dr. T.J. ‘Jock’ Murray is a 2014 inductee to the Canadian Medical Hall of Fame

Teva announces supreme court denial of request for interim relief to stay

INforMS, Partners

Biogen Idec to present new clinical data at AAN Annual Meeting

INforMS, Partners

New continuing education program helps distinguish between primary care needs & multiple sclerosis symptoms

CMSC PR, Partners

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